![]() ![]() Currently, natural products are often used as starting points for drug discovery followed by synthetic modifications to help reduce side effects and increase bioavailabilty. Thus, natural products have been utilized in both traditional and modern medicine for treating diseases. In fact, the structural diversity of natural products far exceeds the capabilities of synthetic organic chemists within the laboratory. Natural products have high structural diversity and unique pharmacological or biological activities due to the natural selection and evolutionary processes that have shaped their utility over hundreds of thousands of years. The science of organic chemistry, in fact, has its origins in the study of natural products, and has given rise to the fields of synthetic organic chemistry where scientists create organic molecules in the laboratory, and semi-synthetic organic chemistrywhere scientists modify existing natural products to improve or alter their activities. ![]() A more restrictive definition of a natural productis any organic compound that is synthesized by a living organism. milk, plant exudates), and other natural materials that were once found in living organisms (e.g. bioplastics, cornstarch), bodily fluids (e.g. What is a natural product chemistry and why should we be interested in studying it? The broadest definition of a natural productis anything that is produced by life, and includes biotic materials (e.g. Chapter 6: A Brief History of Natural Products and Organic Chemistry 6.1 Definition and Uses 6.2 Natural Product Function 6.3 Primary Metabolites 6.4 Secondary Metabolites 6.5 Where Do We Find Natural Products? Prokaryotic Organisms Bacteria Archaea Eukaryotic Organisms Fungi Plants Animals 6.6 Foundations in Organic and Natural Products Chemistry Early Investigations Structural Theories Expanding the Concept Milestones 6.7 Chapter Summary 6.8 References ![]()
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